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Y chromosome microdeletion : ウィキペディア英語版 | Y chromosome microdeletion Y chromosome microdeletion ''(YCM)'' is a family of genetic disorders caused by missing gene(s) in the Y chromosome. Many men with YCM exhibit no symptoms and lead normal lives. However, YCM is also known to be present in a significant number of men with reduced fertility.〔Carlo Foresta, et al.: (Y chromosome microdeletions and alterations of spermatogenesis ). Endocrine Reviews 22 (2): 226-239.〕 Men with reduced sperm production (in up to 20% of men with reduced sperm count, some form of YCM has been detected) varies from oligozoospermia, significant lack of sperm, or azoospermia, complete lack of sperm. ==Cause== The mechanism of mutation is not different for Y-chromosome microdeletion. However, the ability to repair it differs from other chromosomes. The human Y chromosome is passed directly from father to son, and is not protected against accumulating copying errors, whereas other chromosomes are error corrected by recombining genetic information from mother and father. This may leave natural selection as the primary repair mechanism for the Y chromosome.
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